Nerve Fiber Testing

Small Fiber Neuropathy

Small Fiber Neuropathy (SFN) is a type of Peripheral Neuropathy. Small fibers send messages about illness and injury and control our internal organs that regulate activities such as breathing, digesting food and heart and gland functions. Symptoms of SFN include pain, burning, tingling and numbness. These symptoms often start in the feet and progress up the rest of the body. Symptoms are often worse at night and affect sleep.

The Procedure

The biopsy is minimally invasive and performed using a 3mm punch tool.
Your skin will be numbed with a local anesthetic which alleviates the pain during the biopsy. The procedure will take the provider approximately 90 seconds to perform, with the entire procedure taking about 10-15 minutes. The biopsy site will be covered with a band-aid and will not require any special treatment.


  • Diabetes Mellitus
  • Pre-diabetes Mellitus
  • Metabolic Syndrome
  • Connective Tissue Diseases
  • Vitamin B12 Defciency
  • HIV Infection
  • Drug Neurotoxic Exposure
  • Celiac Disease
  • Hereditary Diseases
  • Alcohol Abuse


  • Your provider will cover the biopsy sites with a bandage after the procedure.
  • Refrain from doing strenuous activity for the rest of the day following your biopsy, such as running or heavy lifting.
  • Change bandages daily starting the day after the biopsy until the site is completely healed
  • The average time for daily bandage change can take up to two weeks.


S&G Labs Hawaii will provide the results of your Epidermal Nerve Fiber Density test to your provider in approximately 3 weeks, following the procedure. A follow up appointment will be scheduled with your provider to review the results.

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